Current evidence-based practices for obesity management involve multi-modal approaches, including lifestyle modification, mechanical gastric restriction, modulation in the secretion of multiple gut hormones, alteration in the composition and secretion of bile acids, and alterations of the gut microbiome
GLP-1 medications support meaningful weight loss when paired with provider-guided dosing, adherence, and behavior change
It does so by slowing the rate at which food exits your stomach and blocking glucagon (a hormone that causes your liver to release sugar), resulting in you feeling full for longer periods of time and ultimately leading to weight loss
This sustained action leads to a more consistent elevation of GH levels without the sharp peaks and troughs associated with short-acting GHRH analogs
Fullness signals arrive earlier, and eating past them is a common cause of nausea
Generic Availability and Cost Lisdexamfetamine now has generics in the U.S., which has improved access, but shortages still occur